Exocrine ontogenies: On the development of pancreatic acinar, ductal and centroacinar cells

被引：57

作者：

Cleveland, Megan H. ^{[1
,2
]}

Sawyer, Jacob M. ^{[1
]}

Afelik, Solomon

Jensen, Jan

Leach, Steven D. ^{[1
]}

机构：

[1] Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[2] Cleveland Clin, Lerner Res Inst, Predoctoral Training Program Human Genet, Cleveland, OH 44106 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 06期

关键词：

Acinar; Ductal; Centroacinar; Notch; REGENERATING RAT PANCREAS; PROGENITOR CELLS; BETA-CELL; ENDOCRINE-CELLS; BRANCHING MORPHOGENESIS; SIGNALING MAINTAINS; LINEAGE SELECTION; PROTEIN-SYNTHESIS; MOUSE PANCREAS; ADULT PANCREAS;

D O I：

10.1016/j.semcdb.2012.06.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review summarizes our current understanding of exocrine pancreas development, including the formation of acinar, ductal and centroacinar cells. We discuss the transcription factors associated with various stages of exocrine differentiation, from multipotent progenitor cells to fully differentiated acinar and ductal cells. Within the branching epithelial tree of the embryonic pancreas, this involves the progressive restriction of multipotent pancreatic progenitor cells to either a central "trunk" domain giving rise to the islet and ductal lineages, or a peripheral "tip" domain giving rise to acinar cells. This review also discusses the soluble morphogens and other signaling pathways that influence these events. Finally, we examine centroacinar cells as an enigmatic pancreatic cell type whose lineage remains uncertain, and whose possible progenitor capacities continue to be explored. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：711 / 719

页数：9

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