Peptide-enhanced cellular internalization of proteins in neuroscience

被引:48
作者
Dietz, GPH [1 ]
Bähr, M [1 ]
机构
[1] Neurol Univ Klin, D-37073 Gottingen, Germany
关键词
protein delivery; Trojan Horse; HIV-Tat; Antennapedia (penetratin); arginine-rich peptide; ischemia;
D O I
10.1016/j.brainresbull.2005.08.015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Over the last 15 years, many publications described the use of peptide sequences that have been dubbed cell penetrating peptides (CPP), Trojan Horse peptides, protein transduction domains, or membrane-translocating sequences. These mostly positively charged domains bring attached cargo across biological membranes. One of the reasons for the interest in CPP is their potential as delivery tools to enhance the pharmacodynamics of drugs otherwise poorly bioavailable. In particular, the neuroscientist aiming to deliver a protein or other compound into the brain for analytical or therapeutic reasons is faced with the challenge that few drugs cross the blood-brain barrier. CPP are valuable tools to overcome the plasma membrane or the blood-brain barrier in basic research, and in relevant models of neural disease, and will hopefully help to increase the precious few treatments or even cures for people with diseases of the brain and nervous system. Here, we review applications in neuroscience and recent insights into the mechanism of CPP-mediated trafficking. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:103 / 114
页数:12
相关论文
共 202 条
[51]   Proteins linked to a protein transduction domain efficiently transduce pancreatic islets [J].
Embury, J ;
Klein, D ;
Pileggi, A ;
Ribeiro, M ;
Jayaraman, S ;
Molano, RD ;
Fraker, C ;
Kenyon, N ;
Ricordi, C ;
Inverardi, L ;
Pastori, RL .
DIABETES, 2001, 50 (08) :1706-1713
[52]  
EUGENIN EA, 2004, GLIA, V1, P1
[53]   In vivo protein transduction: Biologically active intact PEP-1-superoxide dismutase fusion protein efficiently protects against ischemic insult [J].
Eum, WS ;
Kim, DW ;
Hwang, IK ;
Yoo, KY ;
Kang, TC ;
Jang, SH ;
Choi, HS ;
Choi, SH ;
Kim, YH ;
Kim, SY ;
Kwon, HY ;
Kang, JH ;
Kwon, OS ;
Cho, SW ;
Lee, KS ;
Park, R ;
Won, MH ;
Choi, SY .
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (10) :1656-1669
[54]   TAT-MEDIATED DELIVERY OF HETEROLOGOUS PROTEINS INTO CELLS [J].
FAWELL, S ;
SEERY, J ;
DAIKH, Y ;
MOORE, C ;
CHEN, LL ;
PEPINSKY, B ;
BARSOUM, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :664-668
[55]   Structure-activity relationship of truncated and substituted analogues of the intracellular delivery vector Penetratin [J].
Fischer, PM ;
Zhelev, NZ ;
Wang, S ;
Melville, JE ;
Fåhraeus, R ;
Lane, DP .
JOURNAL OF PEPTIDE RESEARCH, 2000, 55 (02) :163-172
[56]   A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides [J].
Fischer, R ;
Köhler, K ;
Fotin-Mleczek, M ;
Brock, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12625-12635
[57]   Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins [J].
Fittipaldi, A ;
Ferrari, A ;
Zoppé, M ;
Arcangeli, C ;
Pellegrini, V ;
Beltram, F ;
Giacca, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (36) :34141-34149
[58]   Decoding the entry of two novel cell-penetrating peptides in HeLa cells: Lipid raft-mediated endocytosis and endosomal escape [J].
Foerg, C ;
Ziegler, U ;
Fernandez-Carneado, J ;
Giralt, E ;
Rennert, R ;
Beck-Sickinger, AG ;
Merkle, HP .
BIOCHEMISTRY, 2005, 44 (01) :72-81
[59]   Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: A potential vector for delivering heterologous proteins to neurons [J].
Francis, JW ;
Brown, RH ;
Figueiredo, D ;
Remington, MP ;
Castillo, O ;
Schwarzschild, MA ;
Fishman, PS ;
Murphy, JR ;
vanderSpek, JC .
JOURNAL OF NEUROCHEMISTRY, 2000, 74 (06) :2528-2536
[60]   Tetanus toxin fragment C as a vector to enhance delivery of proteins to the CNS [J].
Francis, JW ;
Bastia, E ;
Matthews, CC ;
Parks, DA ;
Schwarzschild, MA ;
Brown, RH ;
Fishman, PS .
BRAIN RESEARCH, 2004, 1011 (01) :7-13