TCDD-inducible poly(ADP-ribose) polymerase:: A novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

被引:114
作者
Ma, Q [1 ]
Baldwin, KT
Renzelli, AJ
McDaniel, A
Dong, LQ
机构
[1] Ctr Dis Control & Prevent, Receptor Biol Lab, Toxicol & Mol Biol Branch,Hlth Effects Lab Div, NIOSH, Morgantown, WV 26505 USA
[2] Integra LifeSci Corp, San Diego, CA 92121 USA
关键词
TiPARP; PARP; TCDD; Ah receptor; RM1; TIL;
D O I
10.1006/bbrc.2001.5987
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes pleotropic effects in mammalian species through modulating gene expression. Here we analyzed TCDD-induced mRNA expression by using mRNA differential display and report the cloning of a novel TCDD-inducible poly(ADP-ribose) polymerase (TiPARP). TiPARP cDNA contains an open reading frame of 657 amino acid residues; the carboxyl half shares sequence similarity to the catalytic domain of PARP, a family of enzymes that catalyze poly ADP-ribosylation of proteins. Expression of the cDNA by in vitro transcription/translation reveals a protein of similar to 75 kDa. The expressed TiPARP exhibits PARP activity toward histone. TiPARP is highly homologous to RM1 which is induced during long-term potentiation, a memory formation process, and to TIL which is induced in T cells infiltrating progressing tumors. TiPARP mRNA is expressed in a broad range of mouse tissues. Together, these data demonstrate that TiPARP is a novel target of TCDD that may contribute to multiple responses to TCDD by modulating protein function through Poly ADP-ribosylation. (C) 2001 Elsevier Science.
引用
收藏
页码:499 / 506
页数:8
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