Interstitial leukocyte migration and immune function

被引：414

作者：

Friedl, Peter ^{[1
]}

Weigelin, Bettina

机构：

[1] Radboud Univ Nijmegen, Dept Cell Biol, Nijmegen Ctr Mol Life Sci, Med Ctr, NL-6500 HB Nijmegen, Netherlands

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 09期

关键词：

D O I：

10.1038/ni.f.212

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The trafficking of leukocytes into and within lymphoid and peripheral tissues is central to immune cell development, immunosurveillance and effector function. Interstitial leukocyte trafficking is the result of amoeboid polarization and migration, guided by soluble or tissue-bound chemoattractant signals for positioning and local arrest. In contrast to other migration modes, amoeboid movement is particularly suited for scanning cellular networks and tissues. Here, we review mechanisms of leukocyte migration and sensing involved in diapedesis, tissue-based interstitial migration and egress, immune cell positioning in inflammation, and emerging therapeutic interference strategies.

引用

页码：960 / 969

页数：10

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