Engineered membrane superchannel improves bioremediation potential of dioxin-degrading bacteria

被引：41

作者：

Aso, Y

Miyamoto, Y

Harada, KM

Momma, K

Kawai, S

Hashimoto, W

Mikami, B

Murata, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Lab Basic & Appl Mol Biotechnol, Uji, Kyoto 6110011, Japan

[2] Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Uji, Kyoto 6110011, Japan

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 02期

关键词：

D O I：

10.1038/nbt1181

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sphingomonas sp. A1 possesses specialized membrane structures termed 'superchannels' that enable the direct incorporation of macromolecules into the cell. We have engineered two related sphingomonads, the dioxin-degrading S. wittichii RW1 and the polypropylene glycol-degrading S. subarctica IFO 16058(T), to incorporate this superchannel into their cell membranes. In both cases the bioremediation capability of the organisms was substantially increased pointing at the potential of this approach as a general strategy to improve bacterial degradation of hazardous compounds in the environment.

引用

页码：188 / 189

页数：2

共 15 条

[11] Direct evidence for Sphingomonas sp A1 periplasmic proteins as macromolecule-binding proteins associated with the ABC transporter:: Molecular insights into alginate transport in the periplasm [J].