Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. (II)

被引：9

作者：

Jin, YH

Hada, N

Oka, J

Kanie, O

Daikoku, S

Kanie, Y

Yamada, H

Takeda, T

机构：

[1] Kyushu Kyoritsu Univ, Minato Ku, Tokyo 1058512, Japan

[2] Mitsubishi Kagaku Inst Life Sci, MITILS, Machida, Tokyo 1948511, Japan

[3] Kitasato Inst, Oriental Med Res Ctr, Tokyo 1088642, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 04期

关键词：

Bupleurum falcatum; glycocluster; glycodendrimer; beta-alanine derivative; chemical synthesis;

D O I：

10.1248/cpb.54.485

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stereocontrolled syntheses of model compounds related to a major antigenic epitope against antibupleurum 2IIc/PG-1-IgG from antiulcer pectic polysaccharide are described. A trisaccharide derivative (13) was prepared as a precursor and a novel and simple approach for the rational design of a glycocluster and glycodendrimer was developed, through the syntheses of the fluorescence-labeled glycocluster (2) and glycodendrimer (3).

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收藏

页码：485 / 492

页数：8

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