Alveolar cleft osteoplasty using tissue-engineered osteogenic material

被引:133
作者
Hibi, H
Yamada, Y
Ueda, M
Endo, Y
机构
[1] Nagoya Univ, Sch Med, Ctr Genet & Regenerat Med, Showa Ku, Nagoya, Aichi 4668560, Japan
[2] Nagoya Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, Nagoya, Aichi, Japan
关键词
D O I
10.1016/j.ijom.2005.12.007
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The use of tissue-engineered osteogenic material comprising platelet-rich plasma and autologous mesenchymal stem cells isolated, expanded and induced to osteogenic potential in bone augmentation procedures as a replacement for autologous bone grafts, offers predictable results with minimal donor-site morbidity. This material was applied for an alveolar cleft osteoplasty of a 9-year-old female patient. Serial computed tomograms showed the regenerated bone extending from the cleft walls after 3 months and bridging the cleft after 6 months, with 79.1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge.
引用
收藏
页码:551 / 555
页数:5
相关论文
共 19 条
[11]   Multilineage potential of adult human mesenchymal stem cells [J].
Pittenger, MF ;
Mackay, AM ;
Beck, SC ;
Jaiswal, RK ;
Douglas, R ;
Mosca, JD ;
Moorman, MA ;
Simonetti, DW ;
Craig, S ;
Marshak, DR .
SCIENCE, 1999, 284 (5411) :143-147
[12]   Tissue-engineered bone for maxillary sinus augmentation [J].
Schimming, R ;
Schmelzeisen, R .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2004, 62 (06) :724-729
[13]   Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation - a preliminary report [J].
Schmelzeisen, R ;
Schimming, R ;
Sittinger, M .
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 2003, 31 (01) :34-39
[14]   Bone volume after secondary bone grafting in unilateral and bilateral clefts determined by computed tomography scans [J].
Van der Meij, AJW ;
Baart, JA ;
Prahl-Andersen, B ;
Valk, J ;
Kostense, PJ ;
Tuinzing, DB .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 2001, 92 (02) :136-141
[15]  
von Arx T, 1996, Int J Oral Maxillofac Implants, V11, P387
[16]   Biological and biophysical principles in extracorporal bone tissue engineering Part II [J].
Wiesmann, HP ;
Joos, U ;
Meyer, U .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2004, 33 (06) :523-530
[17]   Translational research for injectable tissue-engineered bone regeneration using mesenchymal stem cells and platelet-rich plasma: From basic research to clinical case study [J].
Yamada, Y ;
Ueda, M ;
Hibi, H ;
Nagasaka, T .
CELL TRANSPLANTATION, 2004, 13 (04) :343-355
[18]   Combining orthodontic tooth movement with distraction osteogenesis to close cleft spaces and improve maxillary arch form in cleft lip and palate patients [J].
Yen, SLK ;
Yamashita, DD ;
Gross, J ;
Meara, JG ;
Yamazaki, K ;
Kim, TH ;
Reinisch, J .
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 2005, 127 (02) :224-232
[19]  
Zeitler D., 2000, ORAL MAXILLOFACIAL S, V6, P75