η4-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

被引：64

作者：

Fairlamb, IJS ^{[1
]}

Duhme-Klair, AK

Lynam, JM

Moulton, BE

O'Brien, CT

Sawle, P

Hammad, J

Motterlini, R

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] Northwick Pk Inst Med Res, Dept Surg Res, Vasc Biol Unit, Harrow HA1 3UJ, Middx, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

vasorelaxation; carbon monoxide; transiton metal carbonyl complexes; therapeutic agents;

D O I：

10.1016/j.bmcl.2005.10.085

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta(4)-2-pyrone)Fe(CO)(3) Complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：995 / 998

页数：4

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