Influenza in the acute hospital setting

被引:326
作者
Salgado, CD [1 ]
Farr, BM [1 ]
Hall, KK [1 ]
Hayden, FG [1 ]
机构
[1] Univ Virginia Hlth Syst, Charlottesville, VA 22908 USA
关键词
D O I
10.1016/S1473-3099(02)00221-9
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Influenza poses special hazards inside healthcare facilities and can cause explosive outbreaks of illness. Healthcare workers are at risk of acquiring influenza and thus serve as an important reservoir for patients under their care. Annual influenza immunisation of high-risk persons and their contacts, including healthcare workers, is the primary means of preventing nosocomial influenza. Despite influenza vaccine effectiveness, it is substantially underused by healthcare providers. Influenza can be diagnosed by culturing the virus from respiratory secretions and by rapid antigen detection kits; recognition of a nosocomial outbreak is important in order to employ infection-control efforts. Optimal control of influenza in the acute-care setting should focus upon reducing potential influenza reservoirs in the hospital, including: isolating patients with suspected or documented influenza, sending home healthcare providers or staff who exhibit typical symptoms of influenza, and discouraging persons with febrile respiratory illness from visiting the hospital during a known influenza outbreak in the community. (Note: influenza and other respiratory viruses can cause nonfebrile illness but are still transmissible.) The antiviral M2 protein inhibitors (amantadine, rimantadine) and neuraminidase inhibitors (zanamivir, oseltamivir) have proven efficacy in treating and preventing influenza illness; however, their role in the prevention and control of influenza in the acute hospital setting remains to be more fully studied.
引用
收藏
页码:145 / 155
页数:11
相关论文
共 97 条
  • [41] HEMMES J, 1960, NATURE, V4748, P430
  • [42] INFLUENZAL PNEUMONIA AS A COMPLICATION OF AUTOLOGOUS BONE-MARROW TRANSPLANTATION
    HIRSCHHORN, LR
    MCINTOSH, K
    ANDERSON, KG
    DERMODY, TS
    [J]. CLINICAL INFECTIOUS DISEASES, 1992, 14 (03) : 786 - 787
  • [43] ISON MG, 2001, 41 INT C ANT AG CHEM, P289
  • [44] Short-term treatment with zanamivir to prevent influenza: Results of a placebo-controlled study
    Kaiser, L
    Henry, D
    Flack, NP
    Keene, O
    Hayden, FG
    [J]. CLINICAL INFECTIOUS DISEASES, 2000, 30 (03) : 587 - 589
  • [45] NOSOCOMIAL OUTBREAK OF INFLUENZA-A
    KAPILA, R
    LINTZ, DI
    TECSON, FT
    ZISKIN, L
    LOURIA, DB
    [J]. CHEST, 1977, 71 (05) : 576 - 579
  • [46] INFLUENZA IN CHILDREN WITH CANCER
    KEMPE, A
    HALL, CB
    MACDONALD, NE
    FOYE, HR
    WOODIN, KA
    COHEN, HJ
    LEWIS, ED
    GULLACE, M
    GALA, CL
    DULBERG, CS
    KATSANIS, E
    [J]. JOURNAL OF PEDIATRICS, 1989, 115 (01) : 33 - 39
  • [47] Comparison of central nervous system adverse effects of amantadine and rimantadine used as sequential prophylaxis of influenza A in elderly nursing home patients
    Keyser, LA
    Karl, M
    Nafziger, AN
    Bertino, JS
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (10) : 1485 - 1488
  • [48] PROLONGED SHEDDING OF AMANTADINE-RESISTANT INFLUENZA-A VIRUSES BY IMMUNODEFICIENT PATIENTS - DETECTION BY POLYMERASE CHAIN-REACTION - RESTRICTION ANALYSIS
    KLIMOV, AI
    ROCHA, E
    HAYDEN, FG
    SHULT, PA
    ROUMILLAT, LF
    COX, NJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (05) : 1352 - 1355
  • [49] ROUTINE DIAGNOSIS OF 7 RESPIRATORY VIRUSES AND MYCOPLASMA-PNEUMONIAE BY ENZYME-IMMUNOASSAY
    KOK, T
    MICKAN, LD
    BURRELL, CJ
    [J]. JOURNAL OF VIROLOGICAL METHODS, 1994, 50 (1-3) : 87 - 100
  • [50] Influenza vaccination among healthy employees: A cost-benefit analysis
    Kumpulainen, V
    Makela, M
    [J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1997, 29 (02) : 181 - 185