Synthesis and acetylcholinesterase inhibitory activity of fluorinated analogues of huperzine A

被引：21

作者：

Kaneko, S ^{[1
]}

Nakajima, N ^{[1
]}

Shikano, M ^{[1
]}

Katoh, T ^{[1
]}

Terashima, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期

关键词：

D O I：

10.1016/0960-894X(96)00337-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three novel fluorinated analogues of huperzine A ( 1 ), (+/-)-12, 12, 12-trifluorohuperzine A ( 2 ), (+/-)-14,14,14-trifluorohuperzine A ( 3 ), and (+/-)-12,12,12,14,14,14-hexafluorohuperzine A ( 4 ), have been synthesized by employing TMSCF(3) as a trifluoromethylating agent. These analogues were found to still retain anti-acetylcholinesterase activity. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1927 / 1930

页数：4

共 24 条

[21] THE 1ST CF3-SUBSTITUTED ORGANYL(CHLORO)SILANES [J].