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The FHA domain

被引：335
作者：
Durocher, D
Jackson, SP
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Programme Mol Biol & Canc, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON, Canada
[3] Wellcome CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England
[4] Univ Cambridge, Dept Zool, Cambridge, England
来源：
FEBS LETTERS | 2002年 / 513卷 / 01期
关键词：
phosphorylation; signal transduction; protein : protein interaction; kinase; forkhead-associated domain; kinesin; checkpoint; DNA repair;
D O I：
10.1016/S0014-5793(01)03294-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain-mediated phospho-dependent assembly of protein complexes is an ancient and widespread regulatory mechanism. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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页码：58 / 66
页数：9
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