Mesenchymal stem cells for cartilage regeneration

被引：190

作者：

Le, Hanxiang ^{[1
,2
]}

Xu, Weiguo ^{[2
]}

Zhuang, Xiuli ^{[2
]}

Chang, Fei ^{[1
]}

Wang, Yinan ^{[3
,4
]}

Ding, Jianxun ^{[2
]}

机构：

[1] Second Hosp Jilin Univ, Dept Orthoped, 218 Ziqiang St, Changchun 130041, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun, Peoples R China

[3] First Hosp Jilin Univ, Dept Biobank, Div Clin Res, 71 Xinmin St, Changchun 130041, Peoples R China

[4] First Hosp Jilin Univ, Minist Educ, Key Lab Organ Regenerat & Transplantat, Changchun, Peoples R China

来源：

JOURNAL OF TISSUE ENGINEERING | 2020年 / 11卷

关键词：

Mesenchymal stem cell; chondrogenic factor; cartilage injury; cartilage tissue engineering; cartilage regeneration; PLATELET-RICH PLASMA; INDUCE CHONDROGENIC DIFFERENTIATION; ARTICULAR-CARTILAGE; HYALURONIC-ACID; STROMAL CELLS; FIBRIN GLUE; MICROFRACTURE TECHNIQUE; MSC CHONDROGENESIS; HUMAN CHONDROCYTES; II COLLAGEN;

D O I：

10.1177/2041731420943839

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune diseases. Owing to the avascular structure and low metabolic activities of chondrocytes, cartilage generally does not self-repair following an injury. Currently, clinical interventions for cartilage injuries include chondrocyte implantation, microfracture, and osteochondral transplantation. However, rather than restoring cartilage integrity, these methods only postpone further cartilage deterioration. Stem cell therapies, especially mesenchymal stem cell (MSCs) therapies, were found to be a feasible strategy in the treatment of cartilage injuries. MSCs can easily be isolated from mesenchymal tissue and be differentiated into chondrocytes with the support of chondrogenic factors or scaffolds to repair damaged cartilage tissue. In this review, we highlighted the full success of cartilage repair using MSCs, or MSCs in combination with chondrogenic factors and scaffolds, and predicted their pros and cons for prospective translation to clinical practice.

引用

页数：22

共 122 条

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