Autophagy, Myocardial Protection, and the Metabolic Syndrome

被引：69

作者：

Giricz, Zoltan ^{[1
]}

Mentzer, Robert M., Jr. ^{[1
,2
,3
]}

Gottlieb, Roberta A. ^{[1
]}

机构：

[1] San Diego State Univ, Donald P Shiley BioSci Ctr, Dept Biol, San Diego, CA 92182 USA

[2] Wayne State Univ, Sch Med, Dept Physiol, Cardiovasc Res Inst, Detroit, MI 48201 USA

[3] Wayne State Univ, Sch Med, Dept Surg, Detroit, MI 48201 USA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2012年 / 60卷 / 02期

关键词：

autophagy; cardioprotection; metabolic syndrome; myocardial ischemia and reperfusion; ACTIVATED PROTEIN-KINASE; ISCHEMIA-REPERFUSION INJURY; TERM CALORIC RESTRICTION; OXIDATIVE STRESS; DIABETIC HEART; ISCHEMIA/REPERFUSION INJURY; MITOCHONDRIAL DYSFUNCTION; ROSIGLITAZONE TREATMENT; DIFFERENTIAL ROLES; INSULIN-RESISTANCE;

D O I：

10.1097/FJC.0b013e318256ce10

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Autophagy is a housekeeping process that helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart's tolerance to ischemia are also discussed.

引用

页码：125 / 132

页数：8

共 116 条

[1]

Mitochondrial Dysfunction, Insulin Resistance, and Type 2 Diabetes Mellitus [J].

Abdul-Ghani, Muhammad A. ;

DeFronzo, Ralph A. .

CURRENT DIABETES REPORTS, 2008, 8 (03) :173-178

[2]

Simvastatin Alleviates Myocardial Contractile Dysfunction and Lethal Ischemic Injury in Rat Heart Independent of Cholesterol-Lowering Effects [J].

Adameova, A. ;

Harcarova, A. ;

Matejikova, J. ;

Pancza, D. ;

Kuzelova, M. ;

Carnicka, S. ;

Svec, P. ;

Bartekova, M. ;

Styk, J. ;

Ravingerova, T. .

PHYSIOLOGICAL RESEARCH, 2009, 58 (03) :449-452

[3]

Hydrophobic statins induce autophagy in cultured human rhabdomyosarcoma cells [J].

Araki, Makoto ;

Motojima, Kiyoto .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (02) :462-467

[4]

Metabolic mechanisms in heart failure [J].

Ashrafian, Houman ;

Frenneaux, Michael P. ;

Opie, Lionel H. .

CIRCULATION, 2007, 116 (04) :434-448

[5]

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events [J].

Bach, Markus ;

Larance, Mark ;

James, David E. ;

Ramm, Georg .

BIOCHEMICAL JOURNAL, 2011, 440 :283-291

[6]

Bhamra GS, 2008, BASIC RES CARDIOL, V103, P274, DOI [10.1007/s00395-007-0691-y, 10.1007/s00395-008-0736-x]

[7]

Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice [J].

Bouhidel, Omar ;

Pons, Sandrine ;

Souktani, Richard ;

Zini, Roland ;

Berdeaux, Alain ;

Ghaleh, Bijan .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 295 (04) :H1580-H1586

[8]

Beneficial Effects of Mammalian Target of Rapamycin Inhibition on Left Ventricular Remodeling After Myocardial Infarction [J].

Buss, Sebastian J. ;

Muenz, Sebastian ;

Riffel, Johannes H. ;

Malekar, Pratima ;

Hagenmueller, Marco ;

Weiss, Celine S. ;

Bea, Florian ;

Bekeredjian, Raffi ;

Schinke-Braun, Martina ;

Izumo, Seigo ;

Katus, Hugo A. ;

Hardt, Stefan E. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (25) :2435-2446

[9]

Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling [J].

Calvert, John W. ;

Gundewar, Susheel ;

Jha, Saurabh ;

Greer, James J. M. ;

Bestermann, William H. ;

Tian, Rong ;

Lefer, David J. .

DIABETES, 2008, 57 (03) :696-705

[10]

Cholesterol depletion induces autophagy [J].

Cheng, Jinglei ;

Ohsaki, Yuki ;

Tauchi-Sato, Kumi ;

Fujita, Akikazu ;

Fujimoto, Toyoshi .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 351 (01) :246-252

← 1 2 3 4 5 6 7 8 9 10 →