Synthesis and self-assembly of "tree-like" amphiphilic glycopolypeptides

被引：67

作者：

Bonduelle, Colin ^{[1
,2
]}

Huang, Jin ^{[3
]}

Ibarboure, Emmanuel ^{[1
,2
]}

Heise, Andreas ^{[3
]}

Lecommandoux, Sebastien ^{[1
,2
]}

机构：

[1] Univ Bordeaux IPB, ENSCBP, F-33607 Pessac, France

[2] CNRS, UMR5629, Lab Chim Polymeres Organ, Pessac, France

[3] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 67期

基金：

爱尔兰科学基金会;

关键词：

BLOCK-COPOLYMERS; DRUG-DELIVERY; VESICLES; POLYMERSOMES; DOXORUBICIN; GLYCOPOLYMERS; MICELLES; WATER;

D O I：

10.1039/c2cc32970k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel synthetic tree-like oligosaccharides-grafted-polypeptides were prepared by using Huisgen 1,3-dipolar cycloaddition between poly(gamma-benzyl-L-glutamate)-block-poly(propargylglycine) and two different oligosaccharides, dextran or hyaluronan. By direct solubilisation in water, these tree- ike glycopeptides spontaneously form very small assemblies with sizes below 50 nm and low polydispersity.

引用

收藏

页码：8353 / 8355

页数：3

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