Savior and slayer: the two faces of p53

被引：86

作者：

Bensaad, K ^{[1
]}

Vousden, KH ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE MEDICINE | 2005年 / 11卷 / 12期

关键词：

D O I：

10.1038/nm1205-1278

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Low levels of DNA damage caused by oxidative stress can be repaired, whereas extensive damage usually results in cell death. p53 contributes to both outcomes by stimulating expression of either pro- or antioxidant genes (pages 1306-1313).

引用

页码：1278 / 1279

页数：3

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