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p53: Traffic cop at the crossroads of DNA repair and recombination

被引：405
作者：
Sengupta, S
Harris, CC
机构：
[1] NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA
[2] Natl Inst Immunol, New Delhi 110067, India
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1546
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.
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页码：44 / 55
页数：12
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