p53 in the cytoplasm: A question of overkill?

被引：47

作者：

Baptiste, N ^{[1
]}

Prives, C ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

CELL | 2004年 / 116卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(04)00164-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The tumor suppressor p53 regulates cellular responses to stress by serving in the nucleus to regulate transcription of genes involved in processes including cell cycle arrest, DNA repair, and apoptosis. Nevertheless, recent papers show that p53 may have a separate cytoplasmic role in directly regulating the Bax-dependent mitochondrial pathway to cell death.

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收藏

页码：487 / 489

页数：3

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