p53: Traffic cop at the crossroads of DNA repair and recombination

被引：405

作者：

Sengupta, S

Harris, CC

机构：

[1] NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Immunol, New Delhi 110067, India

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1546

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.

引用

页码：44 / 55

页数：12

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