Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitosan scaffolds for skin regeneration

被引：81

作者：

Veleirinho, Beatriz ^{[1
]}

Coelho, Daniela S. ^{[2
]}

Dias, Paulo F. ^{[2
]}

Maraschin, Marcelo ^{[3
]}

Ribeiro-do-Valle, Rosa M. ^{[4
]}

Lopes-da-Silva, Jose A. ^{[1
]}

机构：

[1] Univ Aveiro, Dept Chem, QOPNA Res Unit, P-3810193 Aveiro, Portugal

[2] Univ Fed Santa Catarina, Dept Cell Biol Embryol & Genet, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Dept Plant Sci, BR-88040900 Florianopolis, SC, Brazil

[4] Univ Fed Santa Catarina, Dept Pharmacol, BR-88040900 Florianopolis, SC, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 04期

关键词：

PHBV; Chitosan; Electrospinning; Scaffold; Skin healing; IN-VITRO; CHITOSAN NANOPARTICLES; POLY; 3-HYDROXYBUTYRATE; FIBER MATS; ANTIBACTERIAL; POLYHYDROXYALKANOATES; BIOCOMPATIBILITY; INFLAMMATION; REPAIR; BLEND;

D O I：

10.1016/j.ijbiomac.2012.05.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The purpose of this study was to evaluate hybrid poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitosan nanofibrous mats as scaffolds for skin engineering. In vitro studies were carried out to test the potential of the scaffolds for fibroblasts adhesion, viability, and proliferation (L929 cell line). The in vivo performance was also studied in a full-thickness wound healing model. PHBV/chitosan 4:1 (w/w) exhibited a higher in vitro biocompatibility and a better ability for cell adhesion and growth, compared to PHBV/chitosan 2:3 (w/w). The in vivo assay also revealed the better performance of this scaffold, improving the wound healing process in rats. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：343 / 350

页数：8

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