The hormonal response to intravenous 5-hydroxytryptophan in bulimia nervosa

被引：11

作者：

Goldbloom, DS ^{[1
]}

Garfinkel, PE ^{[1
]}

Katz, R ^{[1
]}

Brown, GM ^{[1
]}

机构：

[1] UNIV TORONTO,TORONTO HOSP,TORONTO,ON,CANADA

来源：

JOURNAL OF PSYCHOSOMATIC RESEARCH | 1996年 / 40卷 / 03期

基金：

英国医学研究理事会;

关键词：

bulimia nervosa; eating disorders; neuroendocrine; prolactin; 5-hydroxytryptophan; serotonin;

D O I：

10.1016/0022-3999(95)00640-0

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In recent years evidence has accumulated to implicate a disturbance in serotonin function in the eating disorder bulimia nervosa. This study employs a neuroendocrine technique to assess the effect of intravenous 5-hydroxytryptophan, the immediate precursor to serotonin, on peripheral hormones in bulimia nervosa subjects and controls. Blunted prolactin and growth hormone responses were observed among bulimia nervosa subjects; the possible pathophysiology and implications of the findings are discussed.

引用

页码：289 / 297

页数：9

共 53 条

[1] LOW BRAIN UPTAKE OF L-[C-11]5-HYDROXYTRYPTOPHAN IN MAJOR DEPRESSION - A POSITRON EMISSION TOMOGRAPHY STUDY ON PATIENTS AND HEALTHY-VOLUNTEERS [J].