Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water

被引：5

作者：

Chen, Shusen ^{[2
]}

Wang, Yinong ^{[2
]}

Fan, Yunge ^{[2
]}

Ma, Jianbiao ^{[1
]}

机构：

[1] Tianjin Univ Technol, Sch Chem & Chem Engn, 263 S Hongqi Rd, Tianjin 300191, Peoples R China

[2] Nankai Univ, Dept Chem, Inst Polymer Chem, Key Lab Funct Polymer Mat,Minist Educ, Tianjin 300071, Peoples R China

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2009年 / 88A卷 / 03期

关键词：

amphiphilic biodegradable polyester; poly (tetraethylene glycol succinate); thermosensitivity; polymeric micelles; aggregation; DEPENDENT SEQUENCE DESIGN; THERMOREVERSIBLE GELATION; POLY(ETHYLENE GLYCOL); AQUEOUS-SOLUTIONS; BLOCK-COPOLYMERS; SOLID-STATE; B-PEG; BEHAVIOR; OXIDE); DYNAMICS;

D O I：

10.1002/jbm.a.31909

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p-toluenesulfonic acid. It was observed that PTEGSuc could self-assemble into micelles in water. In addition, thermosensitivity of PTEGSUc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 769-777, 2009

引用

页码：769 / 777

页数：9

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