Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease

被引：94

作者：

Khan, NL

Katzenschlager, R

Watt, H

Bhatia, KP

Wood, NW

Quinn, N

Lees, AJ

机构：

[1] Royal Free Hosp & Univ Coll Med Sch, Reta Lila Weston Inst Neurol Studies, Inst Neurol, Dept Mol Neurosci, London W1P 6DB, England

[2] Royal Free Hosp & Univ Coll Med Sch, Reta Lila Weston Inst Neurol Studies, Sobell Dept Motor neurosci & Movement Disorders, Inst Neurol, London W1P 6DB, England

[3] UCL, London Sch Hyg & Trop Med, Dept Stat, London WC1E 6BT, England

来源：

NEUROLOGY | 2004年 / 62卷 / 07期

关键词：

D O I：

10.1212/01.WNL.0000118281.66802.81

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors studied whether olfactory dysfunction is present in parkin disease using the University of Pennsylvania Smell Identification Test (UPSIT). The mean UPSIT score in parkin patients was 27.3 (95% CI 24.4 to 30.2). This did not differ from the normal group mean of 29.4 (95% CI 28.0 to 30.7; p=0.22) but was higher than the Parkinson disease group (mean 14.3; 95% CI 12.2 to 19.5; p<0.0001) and the parkin-negative group (mean 17.1; 95% CI 14.8 to 16.3; p<0.0001) values. Parkin disease may be a distinct and separate entity from Parkinson disease.

引用

页码：1224 / 1226

页数：3