Total synthesis of (±)-welwitindolinone A isonitrile

被引：117

作者：

Reisman, SE ^{[1
]}

Ready, JM ^{[1
]}

Hasuoka, A ^{[1
]}

Smith, CJ ^{[1
]}

Wood, JL ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, Sterling Chem Lab, New Haven, CT 06520 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 05期

关键词：

D O I：

10.1021/ja057640s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly stereoselective total synthesis of the alkaloid natural product welwitindolinone A isonitrile has been completed. The synthesis utilizes a chloronium ion mediated semi-pinacol rearrangement to simultaneously install the C10 quaternary center and neopentyl chlorine and a novel anionic cyclization to construct the spiro-oxindole with complete stereocontrol. Copyright © 2006 American Chemical Society.

引用

页码：1448 / 1449

页数：2

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