Chronic morphine application is protective against cell death in primary human neurons

被引：13

作者：

Cui, Jia

Chen, Qiuyue

Yu, Long-Chuan

Zhang, Yan ^{[1
]}

机构：

[1] Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China

来源：

NEUROREPORT | 2008年 / 19卷 / 18期

基金：

美国国家科学基金会;

关键词：

apoptosis; morphine; neurons; protection;

D O I：

10.1097/WNR.0b013e3283186fd7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Morphine addiction has become a long-time, serious medical and social problem. To understand the cellular mechanisms of morphine application and addiction, the effects of chronic morphine treatments were examined in primary cultured human neurons. Our results show that, surprisingly, morphine protects cultured human neurons against serum deprivation and staurosporine induced cytotoxicity. Morphine downregulates proapoptotic factor Bax levels in cultured human neurons. In addition, heat shock protein 70 is also involved in morphine protection. Our data suggest that chronic morphine application may be beneficial to stimulate cell survival. NeuroReport 19:1745-1749 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

收藏

页码：1745 / 1749

页数：5

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