Palladium-Catalyzed Migratory Insertion of Isocyanides: An Emerging Platform in Cross-Coupling Chemistry

被引：402

作者：

Vlaar, Tjostil ^{[1
,2
]}

Ruijter, Eelco ^{[1
,2
]}

Maes, Bert U. W. ^{[3
]}

Orru, Romano V. A. ^{[1
,2
]}

机构：

[1] Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, AIMMS, NL-1081 HV Amsterdam, Netherlands

[3] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 28期

关键词：

heterocycles; homogeneous catalysis; isocyanides; palladium; synthetic methods; TRANSITION-METAL-COMPLEXES; ARYL HALIDES; LIVING POLYMERIZATION; ISONITRILE INSERTION; SUCCESSIVE INSERTION; 3-COMPONENT REACTION; MULTIPLE INSERTION; CONCISE SYNTHESIS; ALLYL CYANAMIDES; BOND;

D O I：

10.1002/anie.201300942

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Isocyanides have been important building blocks in organic synthesis since the discovery of the Ugi reaction and related isocyanide-based multicomponent reactions. In the past decade isocyanides have found a new application as versatile C-1 building blocks in palladium catalysis. Palladium-catalyzed reactions involving isocyanide insertion offer a vast potential for the synthesis of nitrogen-containing fine chemicals. This Minireview discusses all the achievements in this emerging field.

引用

页码：7084 / 7097

页数：14

共 96 条

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