Ruthenium-catalyzed asymmetric alkene epoxidation with tert-butyl hydroperoxide as oxidant

被引：39

作者：

Bhor, S

Tse, MK

Klawonn, M

Döbler, C

Mägerlein, WB

Beller, M

机构：

[1] Univ Rostock, Leibniz Inst Organ Katalyse, D-18055 Rostock, Germany

[2] Bayer AG, D-51368 Leverkusen, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2004年 / 346卷 / 2-3期

关键词：

asymmetric catalysis; tert-butyl hydroperoxide; epoxidation; homogeneous catalysis; N; O ligands; ruthenium;

D O I：

10.1002/adsc.200303142

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A ruthenium-catalyzed asymmetric epoxidation of various olefins using tert-butyl hydroperoxide (TBHP) as the oxidant is reported. By applying ruthenium(pyridinebisoxazoline)-(pyridinedicarboxylate) complexes 1 [Ru(pybox)(pydic), 1] as catalysts, aromatic and aliphatic olefins yielded the corresponding epoxides at room temperature in good to excellent yields and enantioselectivities up to 65% ee. Slow addition of the stoichiometric oxidant significantly improved the yield and the chemoselectivity of the reaction.

引用

页码：263 / 267

页数：5