Drug targets for Plasmodium falciparum:: A post-genomic review/survey

被引：28

作者：

Yeh, I ^{[1
]}

Altman, RB ^{[1
]}

机构：

[1] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 02期

关键词：

malaria; drug targets; plasmodium; metabolism; genomics;

D O I：

10.2174/138955706775475957

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Over 300 million cases of malaria each year cause significant morbidity and mortality. Growing drug-resistance among the Plasmodia that cause malaria motivates the development of additional anti-malarial drugs. This review summarizes the current state of knowledge about potential drug targets for malaria. The recently sequenced malaria genome data clarifies parasite metabolic pathways. and more metabolic targets have been identified.

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页码：177 / 202

页数：26

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