Drug targets for Plasmodium falciparum:: A post-genomic review/survey

被引:28
作者
Yeh, I [1 ]
Altman, RB [1 ]
机构
[1] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
关键词
malaria; drug targets; plasmodium; metabolism; genomics;
D O I
10.2174/138955706775475957
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Over 300 million cases of malaria each year cause significant morbidity and mortality. Growing drug-resistance among the Plasmodia that cause malaria motivates the development of additional anti-malarial drugs. This review summarizes the current state of knowledge about potential drug targets for malaria. The recently sequenced malaria genome data clarifies parasite metabolic pathways. and more metabolic targets have been identified.
引用
收藏
页码:177 / 202
页数:26
相关论文
共 172 条
[11]   A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum [J].
Berry, C ;
Humphreys, MJ ;
Matharu, P ;
Granger, R ;
Horrocks, P ;
Moon, RP ;
Certa, U ;
Ridley, RG ;
Bur, D ;
Kay, J .
FEBS LETTERS, 1999, 447 (2-3) :149-154
[12]  
BHANOT P, 2004, J BIOL CHEM
[13]   Characterization of the choline carrier of Plasmodium falciparum:: a route for the selective delivery of novel antimalarial chugs [J].
Biagini, GA ;
Pasini, EM ;
Hughes, R ;
De Koning, HP ;
Vial, HJ ;
O'Neill, PM ;
Ward, SA ;
Bray, PG .
BLOOD, 2004, 104 (10) :3372-3377
[14]   5-Substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials [J].
Biot, C ;
Bauer, H ;
Schirmer, RH ;
Davioud-Charvet, E .
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (24) :5972-5983
[15]   Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions [J].
Birkholtz, LM ;
Wrenger, C ;
Joubert, F ;
Wells, GA ;
Walter, RD ;
Louw, AI .
BIOCHEMICAL JOURNAL, 2004, 377 (02) :439-448
[16]   BIS(BENZYL)POLYAMINE ANALOGS INHIBIT THE GROWTH OF CHLOROQUINE-RESISTANT HUMAN MALARIA PARASITES (PLASMODIUM-FALCIPARUM) INVITRO AND IN COMBINATION WITH ALPHA-DIFLUOROMETHYLORNITHINE CURE MURINE MALARIA [J].
BITONTI, AJ ;
DUMONT, JA ;
BUSH, TL ;
EDWARDS, ML ;
STEMERICK, DM ;
MCCANN, PP ;
SJOERDSMA, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (02) :651-655
[17]   Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum [J].
Bodley, AL ;
Cumming, JN ;
Shapiro, TA .
BIOCHEMICAL PHARMACOLOGY, 1998, 55 (05) :709-711
[18]   Import of host δ-aminolevulinate dehydratase into the malarial parasite:: Identification of a new drug target [J].
Bonday, ZQ ;
Dhanasekaran, S ;
Rangarajan, PN ;
Padmanaban, G .
NATURE MEDICINE, 2000, 6 (08) :898-903
[19]   Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria [J].
Borrmann, S ;
Issifou, S ;
Esser, G ;
Adegnika, AA ;
Ramharter, M ;
Matsiegui, PB ;
Oyakhirome, S ;
Mawili-Mboumba, DP ;
Missinou, MA ;
Kun, JFJ ;
Jomaa, H ;
Kremsner, PG .
JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (09) :1534-1540
[20]   The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum [J].
Bowman, S ;
Lawson, D ;
Basham, D ;
Brown, D ;
Chillingworth, T ;
Churcher, CM ;
Craig, A ;
Davies, RM ;
Devlin, K ;
Feltwell, T ;
Gentles, S ;
Gwilliam, R ;
Hamlin, N ;
Harris, D ;
Holroyd, S ;
Hornsby, T ;
Horrocks, P ;
Jagels, K ;
Jassal, B ;
Kyes, S ;
McLean, J ;
Moule, S ;
Mungall, K ;
Murphy, L ;
Oliver, K ;
Quail, MA ;
Rajandream, MA ;
Rutter, S ;
Skelton, J ;
Squares, R ;
Squares, S ;
Sulston, JE ;
Whitehead, S ;
Woodward, JR ;
Newbold, C ;
Barrell, BG .
NATURE, 1999, 400 (6744) :532-538