Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum

被引：58

作者：

Bodley, AL

Cumming, JN

Shapiro, TA

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21205 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 1998年 / 55卷 / 05期

关键词：

Plasmodium falciparum; malaria; topoisomerase; camptothecin;

D O I：

10.1016/S0006-2952(97)00556-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Currently, the treatment of falciparum malaria is seriously compromised by spreading drug resistance. We studied the effects of camptothecin, a potent and specific topoisomerase I inhibitor, on erythrocytic malaria parasites in vitro. In Plasmodium falciparum, camptothecin trapped protein-DNA complexes, inhibited nucleic acid biosynthesis, and was cytotoxic. These results provide proof for the concept that topoisomerase I is a vulnerable target for new antimalarial drug development. (C) 1998 Elsevier Science Inc.

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收藏

页码：709 / 711

页数：3

相关论文

共 16 条

[1] MOLECULAR AND CYTOTOXIC EFFECTS OF CAMPTOTHECIN, A TOPOISOMERASE-I INHIBITOR, ON TRYPANOSOMES AND LEISHMANIA [J].

BODLEY, AL ;

SHAPIRO, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3726-3730

[2] New French government aims to boost research job prospects [J].

Butler, D .

NATURE, 1997, 387 (6633) :535-535

[3] THE GENE ENCODING TOPOISOMERASE-II FROM PLASMODIUM-FALCIPARUM [J].

CHEESMAN, S ;

MCALEESE, S ;

GOMAN, M ;

JOHNSON, D ;

HORROCKS, P ;

RIDLEY, RG ;

KILBEY, BJ .

NUCLEIC ACIDS RESEARCH, 1994, 22 (13) :2547-2551

[4]

CHEN AY, 1991, CANCER RES, V51, P6039

[5] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].

DESJARDINS, RE ;

CANFIELD, CJ ;

HAYNES, JD ;

CHULAY, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718

[6]

Drlica K, 1994, Adv Pharmacol, V29A, P263

[7] ACTIVITY OF QUINOLINE-CONTAINING ANTIMALARIALS AGAINST CHLOROQUINE-SENSITIVE AND CHLOROQUINE-RESISTANT STRAINS OF PLASMODIUM-FALCIPARUM INVITRO [J].

GEARY, TG ;

DIVO, AA ;

JENSEN, JB .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (03) :499-503

[8] Artemether in severe malaria - Still too many deaths [J].

Hoffman, SL .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (02) :124-126

[9] DNA TOPOISOMERASE-TARGETING ANTITUMOR DRUGS CAN BE STUDIED IN YEAST [J].

NITISS, J ;

WANG, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) :7501-7505

[10] Synthesis and antimalarial activity of heteroatom-containing bicyclic endoperoxides [J].

Posner, GH ;

Gonzalez, L ;

Cumming, JN ;

Klinedinst, D ;

Shapiro, TA .

TETRAHEDRON, 1997, 53 (01) :37-50