Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

被引：193

作者：

Butterfield, DA ^{[1
]}

Reed, T

Perluigi, M

De Marco, C

Coccia, R

Cini, C

Sultana, R

机构：

[1] Univ Kentucky, Ctr Membrane Sci, Sanders Brown Ctr Aging, Dept Chem, Lexington, KY 40506 USA

[2] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

[3] Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USA

[4] Univ Roma La Sapienza, Dept Biochem Sci, I-00185 Rome, Italy

来源：

NEUROSCIENCE LETTERS | 2006年 / 397卷 / 03期

关键词：

mild cognitive impairment; lipid peroxidation; oxidative stress; Alzheimer's disease; 4-hydroxynonenol; hippocampus; inferior parietal lobule;

D O I：

10.1016/j.neulet.2005.12.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：170 / 173

页数：4

共 31 条

[1] Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: Implications for Alzheimer's disease
Abdul, HM
Butterfield, DA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2005, 1741 (1-2): : 140 - 148
[2] Cerebrospinal fluid tau and Aβ42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment
Andreasen, N
Minthon, L
Vanmechelen, E
Vanderstichele, H
Davidsson, P
Winblad, B
Blennow, K
[J]. NEUROSCIENCE LETTERS, 1999, 273 (01) : 5 - 8
[3] Cerebrospinal fluid β-amyloid(1-42) in Alzheimer disease -: Differences between early- and late-onset Alzheimer disease and stability during the course of disease
Andreasen, N
Hesse, C
Davidsson, P
Minthon, L
Wallin, A
Winblad, B
Vanderstichele, H
Vanmechelen, E
Blennow, K
[J]. ARCHIVES OF NEUROLOGY, 1999, 56 (06) : 673 - 680
[4] EVIDENCE OF AN OXIDATIVE CHALLENGE IN THE ALZHEIMERS BRAIN
BALAZS, L
LEON, M
[J]. NEUROCHEMICAL RESEARCH, 1994, 19 (09) : 1131 - 1137
[5] Butterfield D.A., 1997, ADV CELL AGING GERON, V2, P161
[6] Butterfield DA, 2002, NEUROBIOL AGING, V23, P655
[7] Amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity:: Implications for neurodegeneration in Alzheimer's disease brain.: A review
Butterfield, DA
[J]. FREE RADICAL RESEARCH, 2002, 36 (12) : 1307 - 1313
[8] Modulation of phospholipid asymmetry in synaptosomal membranes by the lipid peroxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer's disease
Castegna, A
Lauderback, CM
Mohmmad-Abdul, H
Butterfield, DA
[J]. BRAIN RESEARCH, 2004, 1004 (1-2) : 193 - 197
[9] CHEMISTRY AND BIOCHEMISTRY OF 4-HYDROXYNONENAL, MALONALDEHYDE AND RELATED ALDEHYDES
ESTERBAUER, H
SCHAUR, RJ
ZOLLNER, H
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1991, 11 (01) : 81 - 128
[10] Holtsberg FW, 1998, J NEUROSCI RES, V53, P685, DOI 10.1002/(SICI)1097-4547(19980915)53:6<685::AID-JNR7>3.0.CO

← 1 2 3 4 →