Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

被引：193

作者：

Butterfield, DA ^{[1
]}

Reed, T

Perluigi, M

De Marco, C

Coccia, R

Cini, C

Sultana, R

机构：

[1] Univ Kentucky, Ctr Membrane Sci, Sanders Brown Ctr Aging, Dept Chem, Lexington, KY 40506 USA

[2] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

[3] Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USA

[4] Univ Roma La Sapienza, Dept Biochem Sci, I-00185 Rome, Italy

来源：

NEUROSCIENCE LETTERS | 2006年 / 397卷 / 03期

关键词：

mild cognitive impairment; lipid peroxidation; oxidative stress; Alzheimer's disease; 4-hydroxynonenol; hippocampus; inferior parietal lobule;

D O I：

10.1016/j.neulet.2005.12.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：170 / 173

页数：4