Effects and safety of granulocyte colony-stimulating factor in healthy volunteers

被引:52
作者
Anderlini, Paolo [1 ]
机构
[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Stern Cell Transplantat & Cellular Therapy, Unit 423, Houston, TX 77030 USA
关键词
filgrastim; granulocyte colony-stimulating factor; normal donors; STEM-CELL DONORS; ENDOTHELIAL PROGENITOR CELLS; FACTOR G-CSF; RHG-CSF; T-CELLS; GENE-EXPRESSION; DENDRITIC CELLS; HUMAN MONOCYTES; IN-VIVO; BLOOD;
D O I
10.1097/MOH.0b013e328319913c
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now widely used in normal donors for collection of peripheral blood progenitor cells for allogeneic transplantation and granulocytes for transfusion. Currently available data on biologic and molecular effects, and safety of rhG-CSF in normal healthy volunteers are reviewed. Recent findings In addition to its known activating role on neutrophil kinetics and functional status, rhG-CSF administration can affect monocytes, lymphocytes and the hemostatic system. Granulocyte colony-stimulating factor receptors were identified in a variety of nonmyeloid tissues, although their role and functional activity have not always been well defined. Moreover, rhG-CSF is capable of modulating complex cytokine networks and can impact the inflammatory response. In addition to its known mobilizing role for peripheral blood progenitor cells, rhG-CSF can mobilize dendritic and endothelial progenitor cells as well. On a clinical level, serious rhG-CSF-related adverse events are well described (e.g. splenic rupture) but remain rare. Summary rhG-CSF effects in healthy volunteers, although normally transient and self-limiting, are now believed to be more complex and heterogeneous than previously thought, Although rhG-CSF administration to healthy volunteers continues to have a favorable risk-benefit profile, these new findings have implications for safeguarding the safety of normal individuals.
引用
收藏
页码:35 / 40
页数:6
相关论文
共 56 条
  • [1] Endothelial-like vascular progenitor cells (VPCs) from allogeneic and autologous donors:: Mobilization features distinct from hematopoietic progenitors
    Allan, David S.
    Dube, Pascale
    Roy, Jean
    Busque, Lambert
    Roy, Denis Claude
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (04) : 433 - 439
  • [2] Changes in gene expression pattern following granulocyte colony-stimulating factor administration to normal stem cell sibling donors
    Amariglio, Ninette
    Jacob-Hirsch, Jasmine
    Shimoni, Avichai
    Leiba, Merav
    Rechavi, Gideon
    Nagler, Arnon
    [J]. ACTA HAEMATOLOGICA, 2007, 117 (02) : 68 - 73
  • [3] Biologic and clinical effects of granulocyte colony-stimulating factor in normal individuals
    Anderlini, P
    Przepiorka, D
    Champlin, R
    Korbling, M
    [J]. BLOOD, 1996, 88 (08) : 2819 - 2825
  • [4] Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
    Arpinati, M
    Green, CL
    Heimfeld, S
    Heuser, JE
    Anasetti, C
    [J]. BLOOD, 2000, 95 (08) : 2484 - 2490
  • [5] Soluble adhesion molecules (sICAM-1, sL-Selectin, sE-Selectin, sCD44) in healthy allogenic peripheral stem-cell donors primed with recombinant C-CSF
    Arslan, Ö
    Akan, H
    Arat, M
    Dalva, K
    Özcan, M
    Gürman, G
    Ilhan, O
    Konuk, N
    Beksaç, M
    Uysal, A
    Koç, H
    [J]. CYTOTHERAPY, 2000, 2 (04) : 259 - 265
  • [6] Molecular analysis of the granulocyte colony-stimulating factor receptor
    Avalos, BR
    [J]. BLOOD, 1996, 88 (03) : 761 - 777
  • [7] G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity
    Baumeister, Susanne H. C.
    Hoelig, Kristina
    Bornhaeuser, Martin
    Meurer, Michael
    Rieber, E. Peter
    Schaekel, Knut
    [J]. BLOOD, 2007, 110 (08) : 3078 - 3081
  • [8] Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesis
    Berliner, Nancy
    [J]. BLOOD, 2008, 111 (12) : 5427 - 5432
  • [9] Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-γ
    Boneberg, EM
    Hareng, L
    Gantner, F
    Wendel, A
    Hartung, T
    [J]. BLOOD, 2000, 95 (01) : 270 - 276
  • [10] Hematopoietic stem cell mobilization with G-CSF induces innate inflammation yet suppresses adaptive immune gene expression as revealed by microarray analysis
    Buzzeo, Matthew P.
    Yang, Jie
    Casella, George
    Reddy, Vijay
    [J]. EXPERIMENTAL HEMATOLOGY, 2007, 35 (09) : 1456 - 1465