Biomaterial patches sutured onto the rat stomach induce a set of genes encoding pancreatic enzymes

被引：19

作者：

Löbler, M

Sass, M

Kunze, C

Schmitz, KP

Hopt, UT

机构：

[1] Univ Rostock, Chirurg Klin & Poliklin, Forschungslab, D-18057 Rostock, Germany

[2] Univ Rostock, Inst Biomed Tech, Kompetenzzentrum Biomat, D-18057 Rostock, Germany

来源：

BIOMATERIALS | 2002年 / 23卷 / 02期

关键词：

biomaterial; gastrointestine; differential display; polyhydroxybutyric acid; mRNA; hydrolases;

D O I：

10.1016/S0142-9612(01)00144-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Asymmetric patches of polyhydroxybutyric acid with one smooth and one rough surface were produced by a dipping procedure. These patches were implanted into the rat gastrointestine and tissue samples were generated at distinct time intervals after surgery. The host's response towards the foreign material was analyzed by Differential Display and RNA profiles were compared to each other. One to two weeks after surgery a group of mRNAs encoding pancreatic enzymes was transiently present after biomaterial implantation. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：577 / 583

页数：7

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