Tumor markers for the early detection of bladder cancer

被引:5
作者
Han, KR
Pantuck, AJ
Belldegrun, AS
Rao, JY
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA 90095 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2002年 / 7卷
关键词
tumor markers; bladder cancer; review;
D O I
10.2741/han
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several urine markers have been and are currently being investigated for the diagnosis and prognostication of bladder malignancies. While cystoscopy and urine cytology remain the gold standard in the detection of bladder cancer, cystoscopy is invasive and cytology yields low sensitivities in low-grade disease. The availability of a non-invasive, accurate, office-based test would be ideal. In this review, we discuss markers that are useful in the prevention and detection of transitional cell carcinoma of the bladder. In general, each of the markers has better sensitivities than cytology, but lower specificities. Furthermore, each of these markers must still be used in adjunct with cystoscopy.
引用
收藏
页码:E19 / E26
页数:8
相关论文
共 84 条
[1]   Anti-apoptosis gene, survivin, and prognosis of neuroblastoma [J].
Adida, C ;
Berrebi, D ;
Peuchmaur, M ;
Reyes-Mugica, M ;
Altieri, DC .
LANCET, 1998, 351 (9106) :882-883
[2]   A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J].
Ambrosini, G ;
Adida, C ;
Altieri, DC .
NATURE MEDICINE, 1997, 3 (08) :917-921
[3]  
BADALAMENT RA, 1987, CANCER, V60, P1423, DOI 10.1002/1097-0142(19871001)60:7<1423::AID-CNCR2820600702>3.0.CO
[4]  
2-6
[5]  
BRENTNALL TA, 1995, AM J PATHOL, V147, P561
[6]   Urine cytology - Is it still the gold standard for screening? [J].
Brown, FM .
UROLOGIC CLINICS OF NORTH AMERICA, 2000, 27 (01) :25-+
[7]  
Burchardt M, 2000, CLIN CHEM, V46, P595
[8]  
CAIRNS P, 1994, CANCER RES, V54, P1422
[9]  
Chao D, 2001, Rev Urol, V3, P85
[10]  
Christensen M, 1998, INT J CANCER, V79, P396, DOI 10.1002/(SICI)1097-0215(19980821)79:4<396::AID-IJC15>3.3.CO