Tumor markers for the early detection of bladder cancer

被引：5

作者：

Han, KR

Pantuck, AJ

Belldegrun, AS

Rao, JY

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA 90095 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2002年 / 7卷

关键词：

tumor markers; bladder cancer; review;

D O I：

10.2741/han

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several urine markers have been and are currently being investigated for the diagnosis and prognostication of bladder malignancies. While cystoscopy and urine cytology remain the gold standard in the detection of bladder cancer, cystoscopy is invasive and cytology yields low sensitivities in low-grade disease. The availability of a non-invasive, accurate, office-based test would be ideal. In this review, we discuss markers that are useful in the prevention and detection of transitional cell carcinoma of the bladder. In general, each of the markers has better sensitivities than cytology, but lower specificities. Furthermore, each of these markers must still be used in adjunct with cystoscopy.

引用

页码：E19 / E26

页数：8

共 84 条

[11]

2-D

[12] Clinical evaluation of the BTA TRAK assay and comparison to voided urine cytology and the Bard BTA test in patients with recurrent bladder tumors [J].