Innervated liver plays an inhibitory role in regulation of food intake

被引:11
作者
Meguid, MM
Yang, ZJ
Bellinger, LL
Gleason, JR
Koseki, M
Laviano, A
Oler, A
机构
[1] SUNY HLTH SCI CTR,SYRACUSE,NY
[2] SYRACUSE UNIV,COLL ARTS & SCI,STAT PROGRAM,SYRACUSE,NY
[3] UNIV HOSP,SURG METAB & NUTR LAB,PROGRAM NEUROSCI,DEPT SURG,DALLAS,TX
[4] UNIV HOSP,DEPT PATHOL,DALLAS,TX
[5] BAYLOR COLL DENT,DEPT BIOMED SCI,DALLAS,TX 75246
关键词
D O I
10.1016/S0039-6060(96)80170-X
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. With the onset of eating, the associated rise of dopamine in, the lateral hypothalamus (LHA-DA) is thought to regulate quantity of food consumed per meal. Early release of LHA-DA induced by eating is facilitated by oronasal stimulation; we propose that the subsequent LHA-DA response induced by nutrients in the portal vein. is dampened by the innervated liver. This was tested by measuring LHA-DA in normal rats: during parenteral feeding to bypass oronasal stimulation, while eating during parenteral feeding, and while eating only. Methods. Rats had either total fiver denervation or sham operation, with placement of a jugular vein catheter and LHA-DA microdialysis cannula. After a 3-week recovery period total liver denervated rats were randomized to parenterally fed food only, and parenteral plus food groups each with sham-operated controls in which LHA-DA was measured. Results. No difference in LHA-DA release in food only groups occurred between total liver denervated or sham-operated rats. A significantly higher rise in LHA-DA was observed in total liver denervated versus sham-operated rats in parenterally fed (129% +/- 4% versus 116% +/- 2%; p < 0.05) and parenteral plus food (151% +/- 4% versus 134% +/- 4%; p < 0.05) groups. Conclusions. In total liver denervation. versus sham operation, an increase in LHA-DA release occurs during parenteral feeding and eating during parenteral feeding, suggesting that innervated liver inhibits LHA-DA release.
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页码:202 / 207
页数:6
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