LncRNA SNHG15 Contributes to Immuno-Escape of Gastric Cancer Through Targeting miR141/PD-L1

被引：55

作者：

Dang, Shengchun ^{[1
,2
]}

Malik, Abdul ^{[1
]}

Chen, Jixiang ^{[1
]}

Qu, Jianguo ^{[1
]}

Yin, Kai ^{[1
]}

Cui, Lei ^{[1
]}

Gu, Min ^{[3
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Dept Gen Surg, Zhenjiang 212001, Jiangsu, Peoples R China

[2] Pucheng Hosp, Dept Gen Surg, Weinan 715500, Shaanxi, Peoples R China

[3] Zhenjiang Hosp Tradit Chinese & Western Med, Dept Oncol, Zhenjiang 212001, Jiangsu, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2020年 / 13卷

关键词：

lncRNA SNHG15; gastric cancer; PD-L1; immuno-escape; miR-141; LONG-NONCODING RNAS; INTERNATIONAL AGENCY; CELL-PROLIFERATION; EXPRESSION; PROMOTES; PD-1;

D O I：

10.2147/OTT.S251625

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Introduction: Long non-coding RNAs (lncRNAs) have been demonstrated to participate in many biological processes and severs as important regulators during the progression of gastric cancer. Methods: Here, we introduced human lncRNA SNHG15 which was highly expressed in gastric cancer and cells. Interestingly, the expression of SNHG15 was correlated with programmed cell death ligand 1 (PD-L1), which promotes the resistance of gastric cancer cells to immune responses. Meanwhile, SNHG15 downregulation suppressed the expression of PD-L1 and resistance of immune responses. Results: Further, our results suggested that SNHG15 acted as a competing endogenous RNA (CeRNA) to sponge miR-141, which was downregulated in gastric cancers and negatively correlated to PD-L1. Conclusion: Our results suggested that SNHG15 improved the expression of PD-L1 by inhibiting miR-141, which in turn promoted the resistance of stomach cancer cells to the immune responses.

引用

页码：8547 / 8556

页数：10

共 31 条

[1]

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes [J].