LncRNA SNHG15 Contributes to Immuno-Escape of Gastric Cancer Through Targeting miR141/PD-L1

被引:55
作者
Dang, Shengchun [1 ,2 ]
Malik, Abdul [1 ]
Chen, Jixiang [1 ]
Qu, Jianguo [1 ]
Yin, Kai [1 ]
Cui, Lei [1 ]
Gu, Min [3 ]
机构
[1] Jiangsu Univ, Affiliated Hosp, Dept Gen Surg, Zhenjiang 212001, Jiangsu, Peoples R China
[2] Pucheng Hosp, Dept Gen Surg, Weinan 715500, Shaanxi, Peoples R China
[3] Zhenjiang Hosp Tradit Chinese & Western Med, Dept Oncol, Zhenjiang 212001, Jiangsu, Peoples R China
关键词
lncRNA SNHG15; gastric cancer; PD-L1; immuno-escape; miR-141; LONG-NONCODING RNAS; INTERNATIONAL AGENCY; CELL-PROLIFERATION; EXPRESSION; PROMOTES; PD-1;
D O I
10.2147/OTT.S251625
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
Introduction: Long non-coding RNAs (lncRNAs) have been demonstrated to participate in many biological processes and severs as important regulators during the progression of gastric cancer. Methods: Here, we introduced human lncRNA SNHG15 which was highly expressed in gastric cancer and cells. Interestingly, the expression of SNHG15 was correlated with programmed cell death ligand 1 (PD-L1), which promotes the resistance of gastric cancer cells to immune responses. Meanwhile, SNHG15 downregulation suppressed the expression of PD-L1 and resistance of immune responses. Results: Further, our results suggested that SNHG15 acted as a competing endogenous RNA (CeRNA) to sponge miR-141, which was downregulated in gastric cancers and negatively correlated to PD-L1. Conclusion: Our results suggested that SNHG15 improved the expression of PD-L1 by inhibiting miR-141, which in turn promoted the resistance of stomach cancer cells to the immune responses.
引用
收藏
页码:8547 / 8556
页数:10
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