Long non-coding RNAs in the regulation of the immune response

被引：469

作者：

Heward, James A. ^{[1
]}

Lindsay, Mark A. ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

long noncoding RNA; antisense; lincRNA; inflammation; innate immune response; adaptive immune response; ENHANCER RNAS; GROWTH-ARREST; T-CELLS; TRANSCRIPTOME ANALYSIS; GENE-EXPRESSION; ACTIVATION; EVOLUTION; IDENTIFICATION; REVEALS; GENOME;

D O I：

10.1016/j.it.2014.07.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

It is increasingly clear that long non-coding RNAs (IncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of IncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These IncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein-protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related IncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and IncRNA biology.

引用

页码：408 / 419

页数：12

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