Practical enantiospecific synthesis of RPR 111905: A novel non-peptide substance P antagonist

被引：10

作者：

Mutti, S

Daubie, C

Malpart, J

Radisson, X

机构：

[1] Rhone-Poulenc Rorer - Ctr. de R., Chemical Process - 13, Quai Jules Guesde, 94403 Vitry sur Seine

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(96)02017-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of enantiomerically pure RPR 111905 was achieved in twelve steps with an overall yield of 6.9%. The synthetic strategy was based on a Diels-Alder reaction to generate the bicyclic framework and the asymmetry was introduced by resolution. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8743 / 8746

页数：4

共 10 条

[1]

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[2]

DAUBIE C, UNPUB TETRAHEDRON LE

[3]

MAYER SC, 1994, TETRAHEDRON-ASYMMETR, V5, P519

[4] DIELS-ALDER REACTIVITY OF OXYGENATED DIENES AND FURANS - SYNTHESIS OF OXYGENATED BIPHENYLS [J].