Enantiospecific synthesis of RPR 107880: A new non peptide substance P antagonist

被引:38
作者
Mutti, S
Daubie, C
Decalogne, F
Fournier, R
Rossi, P
机构
[1] Rhône-Poulenc Rorer Ctrl. Res., Chem. and Biochem. Proc. Department, Ctr. Rech. de Vitry-Alfortville 13, 94403 Vitry sur Seine Cedex
关键词
D O I
10.1016/0040-4039(96)00519-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of enantiomerically pure RPR 107880 is described. The synthetic strategy is based on the use of the readily available and inexpensive (R)-(+)-pulegone. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:3125 / 3128
页数:4
相关论文
共 13 条
[1]   A FACILE SYNTHESIS OF "(-)-(R)-5-METHYL-2-CYCLOHEXEN-1-ONE AND RELATED 2-SUBSTITUTED ENONES FROM (+)-PULEGONE [J].
CAINE, D ;
PROCTER, K ;
CASSELL, RA .
JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (14) :2647-2648
[2]   DIASTEREOSELECTIVE AZOMETHINE YLIDE CYCLOADDITIONS TO UNSATURATED, CHIRAL BICYCLIC LACTAMS [J].
FRAY, AH ;
MEYERS, AI .
TETRAHEDRON LETTERS, 1992, 33 (25) :3575-3578
[3]   CHEMISTRY OF ORGANO-SILICON COMPOUNDS .195. "N-(TRIMETHYLSILYLMETHYL)AMINOMETHYL ETHERS AS AZOMETHINE YLIDE SYNTHONS - A NEW AND CONVENIENT ACCESS TO PYRROLIDINE DERIVATIVES [J].
HOSOMI, A ;
SAKATA, Y ;
SAKURAI, H .
CHEMISTRY LETTERS, 1984, (07) :1117-1120
[4]   SODIUM PERBORATE - A CHEAP AND EFFECTIVE REAGENT FOR THE OXIDATION OF ANILINES AND SULFIDES [J].
MCKILLOP, A ;
TARBIN, JA .
TETRAHEDRON LETTERS, 1983, 24 (14) :1505-1508
[5]  
MUTTI S, IN PRESS SYNTH COMM
[6]  
NANGIA A, 1994, SYNTHETIC COMMUN, V24, P1899
[7]   ENANTIOSELECTIVE TOTAL SYNTHESIS OF NATURAL (+)-LUCIDULINE [J].
OPPOLZER, W ;
PETRZILKA, M .
HELVETICA CHIMICA ACTA, 1978, 61 (08) :2755-2762
[8]   PULEGONE OXIDES [J].
REUSCH, W ;
JOHNSON, CK .
JOURNAL OF ORGANIC CHEMISTRY, 1963, 28 (10) :2557-&
[9]   SYNTHESIS OF RPR-100893, PROTOTYPE OF A NEW SERIES OF POTENT AND SELECTIVE NON PEPTIDE NK1 ANTAGONISTS - THE TRIARYLPERHYDROISOINDOLOLS [J].
TABART, M ;
PEYRONEL, JF .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (05) :673-676
[10]  
TERAO Y, 1985, CHEM PHARM BULL, V33, P896