Ring-chain tautomerism of 2-aryl-substituted-hexahydropyrimidines and tetrahydroquinazolines

被引：42

作者：

Göblyös, A ^{[1
]}

Lázár, L ^{[1
]}

Fülöp, F ^{[1
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Sci, H-6701 Szeged, Hungary

来源：

TETRAHEDRON | 2002年 / 58卷 / 05期

基金：

匈牙利科学研究基金会;

关键词：

diamines; tautomerism; pyrimidines; quinazolines;

D O I：

10.1016/S0040-4020(01)01196-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aryl-substituted-1-isopropyl- and 1-phenylhexahydropyrimidines and 3-isopropyl- and 3-phenyl-1,2,3,4-tetrahydroquinazolines proved to be ring-chain tautomeric mixtures in CDCl3 at 300 K, whereas only ring-closed tautomers could be detected for the 1- or 3-methyl-substituted analogues. The ratios of the ring-chain tautomeric forms at equilibrium could be described by the equation log K-x rhosigma(+) + log K-X=H. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1011 / 1016

页数：6

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