Targeting protein-protein interactions by rational design: mimicry of protein surfaces

被引：134

作者：

Fletcher, Steven ^{[1
]}

Hamilton, Andrew D. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2006年 / 3卷 / 07期

关键词：

protein-protein interaction; inhibitor; proteomimetics; surface; recognition;

D O I：

10.1098/rsif.2006.0115

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Protein-protein interactions play key roles in a range of biological processes, and are therefore important targets for the design of novel therapeutics. Unlike in the design of enzyme active site inhibitors, the disruption of protein-protein interactions is far more challenging, due to such factors as the large interfacial areas involved and the relatively fiat and featureless topologies of these surfaces. Nevertheless, in spite of such challenges, there has been considerable progress in recent years. In this review, we discuss this progress in the context of mimicry of protein surfaces: targeting protein-protein interactions by rational design.

引用

页码：215 / 233

页数：19

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