共 101 条
Targeting protein lysine methylation and demethylation in cancers
被引:52
作者:

He, Yunlong
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA

Korboukh, Ilia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA

Jin, Jian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA

Huang, Jing
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA
机构:
[1] Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA
[2] NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA
基金:
美国国家卫生研究院;
关键词:
methylation;
demethylation;
methyltransferase;
demethylase;
cancer;
epigenetics;
NF-KAPPA-B;
G9A HISTONE METHYLTRANSFERASE;
DOMAIN-CONTAINING PROTEINS;
BREAST-CANCER;
TRANSCRIPTIONAL REPRESSION;
SELECTIVE INHIBITORS;
CELL-PROLIFERATION;
STRUCTURAL BASIS;
PROSTATE-CANCER;
SILENCED GENES;
D O I:
10.1093/abbs/gmr109
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
During the last decade, we saw an explosion of studies investigating the role of lysine methylation/demethylation of histones and non-histone proteins, such as p53, NF-kappaB, and E2F1. These 'Ying-Yang' post-translational modifications are important to fine-tuning the activity of these proteins. Lysine methylation and demethylation are catalyzed by protein lysine methyl-transferases (PKMTs) and protein lysine demethylases (PKDMs). PKMTs, PKDMs, and their substrates have been shown to play important roles in cancers. Although the underlying mechanisms of tumorigenesis are still largely unknown, growing evidence is starting to link aberrant regulation of methylation to tumorigenesis. This review focuses on summarizing the recent progress in understanding of the function of protein lysine methylation, and in the discovery of small molecule inhibitors for PKMTs and PKDMs. We also discuss the potential and the caveats of targeting protein lysine methylation for the treatment of cancer.
引用
收藏
页码:70 / 79
页数:10
相关论文
共 101 条
[1]
The tale of two domains - Proteomics and genomics analysis of SMYD2, a new histone methyltransferase
[J].
Abu-Farha, Mohamed
;
Lambert, Jean-Philippe
;
Al-Madhoun, Ashraf S.
;
Elisma, Fred
;
Skerjanc, Ilona S.
;
Figeys, Daniel
.
MOLECULAR & CELLULAR PROTEOMICS,
2008, 7 (03)
:560-572

Abu-Farha, Mohamed
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada
Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

论文数: 引用数:
h-index:
机构:

Al-Madhoun, Ashraf S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

Elisma, Fred
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

Skerjanc, Ilona S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

论文数: 引用数:
h-index:
机构:
[2]
Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors
[J].
Benelkebir, Hanae
;
Hodgkinson, Christopher
;
Duriez, Patrick J.
;
Hayden, Annette L.
;
Bulleid, Rosemary A.
;
Crabb, Simon J.
;
Packham, Graham
;
Ganesan, A.
.
BIOORGANIC & MEDICINAL CHEMISTRY,
2011, 19 (12)
:3709-3716

Benelkebir, Hanae
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

Hodgkinson, Christopher
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

Duriez, Patrick J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Southampton Gen Hosp, Canc Res UK Prot Core Facil, Fac Med, Southampton SO16 6YD, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

Hayden, Annette L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Southampton Gen Hosp, Canc Res UK Ctr, Fac Med, Southampton SO16 6YD, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

Bulleid, Rosemary A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Southampton Gen Hosp, Canc Res UK Ctr, Fac Med, Southampton SO16 6YD, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

Crabb, Simon J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Southampton Gen Hosp, Canc Res UK Ctr, Fac Med, Southampton SO16 6YD, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

Packham, Graham
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Southampton Gen Hosp, Canc Res UK Ctr, Fac Med, Southampton SO16 6YD, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

Ganesan, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[3]
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
[J].
Binda, Claudia
;
Valente, Sergio
;
Romanenghi, Mauro
;
Pilotto, Simona
;
Cirilli, Roberto
;
Karytinos, Aristotele
;
Ciossani, Giuseppe
;
Botrugno, Oronza A.
;
Forneris, Federico
;
Tardugno, Maria
;
Edmondson, Dale E.
;
Minucci, Saverio
;
Mattevi, Andrea
;
Mai, Antonello
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2010, 132 (19)
:6827-6833

Binda, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy European Inst Oncol, I-20139 Milan, Italy

Valente, Sergio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Drug Chem & Technol, I-00185 Rome, Italy European Inst Oncol, I-20139 Milan, Italy

Romanenghi, Mauro
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, I-20139 Milan, Italy European Inst Oncol, I-20139 Milan, Italy

Pilotto, Simona
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy
Univ Roma La Sapienza, Dept Drug Chem & Technol, I-00185 Rome, Italy European Inst Oncol, I-20139 Milan, Italy

Cirilli, Roberto
论文数: 0 引用数: 0
h-index: 0
机构:
Italian Natl Inst Hlth, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy European Inst Oncol, I-20139 Milan, Italy

Karytinos, Aristotele
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy European Inst Oncol, I-20139 Milan, Italy

Ciossani, Giuseppe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy European Inst Oncol, I-20139 Milan, Italy

Botrugno, Oronza A.
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, I-20139 Milan, Italy European Inst Oncol, I-20139 Milan, Italy

Forneris, Federico
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy European Inst Oncol, I-20139 Milan, Italy

Tardugno, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Drug Chem & Technol, I-00185 Rome, Italy European Inst Oncol, I-20139 Milan, Italy

Edmondson, Dale E.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biochem, Atlanta, GA 30322 USA European Inst Oncol, I-20139 Milan, Italy

论文数: 引用数:
h-index:
机构:

Mattevi, Andrea
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy European Inst Oncol, I-20139 Milan, Italy

Mai, Antonello
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Drug Chem & Technol, I-00185 Rome, Italy European Inst Oncol, I-20139 Milan, Italy
[4]
Oncogene-induced senescence as an initial barrier in lymphoma development
[J].
Braig, M
;
Lee, S
;
Loddenkemper, C
;
Rudolph, C
;
Peters, AHFM
;
Schlegelberger, B
;
Stein, H
;
Dörken, B
;
Jenuwein, T
;
Schmitt, CA
.
NATURE,
2005, 436 (7051)
:660-665

Braig, M
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Lee, S
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Loddenkemper, C
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Rudolph, C
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Peters, AHFM
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Schlegelberger, B
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Stein, H
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Dörken, B
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Jenuwein, T
论文数: 0 引用数: 0
h-index: 0
机构: Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany

Schmitt, CA
论文数: 0 引用数: 0
h-index: 0
机构:
Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany Charite Univ Med Berlin Haematol Oncol, D-13353 Berlin, Germany
[5]
Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
[J].
Brown, Mark A.
;
Sims, Robert J., III
;
Gottlieb, Paul D.
;
Tucker, Philip W.
.
MOLECULAR CANCER,
2006, 5 (1)

Brown, Mark A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA

Sims, Robert J., III
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA

Gottlieb, Paul D.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA

Tucker, Philip W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA
[6]
The Methyltransferase Set7/9 (Setd7) Is Dispensable for the p53-Mediated DNA Damage Response In Vivo
[J].
Campaner, Stefano
;
Spreafico, Fabio
;
Burgold, Thomas
;
Doni, Mirko
;
Rosato, Umberto
;
Amati, Bruno
;
Testa, Giuseppe
.
MOLECULAR CELL,
2011, 43 (04)
:681-688

论文数: 引用数:
h-index:
机构:

Spreafico, Fabio
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

Burgold, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

论文数: 引用数:
h-index:
机构:

Rosato, Umberto
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

论文数: 引用数:
h-index:
机构:

Testa, Giuseppe
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy
[7]
Role of histone H3 lysine 27 methylation in polycomb-group silencing
[J].
Cao, R
;
Wang, LJ
;
Wang, HB
;
Xia, L
;
Erdjument-Bromage, H
;
Tempst, P
;
Jones, RS
;
Zhang, Y
.
SCIENCE,
2002, 298 (5595)
:1039-1043

Cao, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

Wang, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

Wang, HB
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

Xia, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

Erdjument-Bromage, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

Tempst, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

Jones, RS
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

Zhang, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
[8]
Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases
[J].
Chang, Yanqi
;
Ganesh, Thota
;
Horton, John R.
;
Spannhoff, Astrid
;
Liu, Jin
;
Sun, Aiming
;
Zhang, Xing
;
Bedford, Mark T.
;
Shinkai, Yoichi
;
Snyder, James P.
;
Cheng, Xiaodong
.
JOURNAL OF MOLECULAR BIOLOGY,
2010, 400 (01)
:1-7

Chang, Yanqi
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Ganesh, Thota
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Chem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Horton, John R.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Spannhoff, Astrid
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Carcinogenesis, Smithville, TX 78957 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Liu, Jin
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Chem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Sun, Aiming
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Chem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Zhang, Xing
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Bedford, Mark T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Carcinogenesis, Smithville, TX 78957 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Shinkai, Yoichi
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Expt Res Ctr Infect Dis, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Snyder, James P.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Chem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA

Cheng, Xiaodong
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Dept Chem, Atlanta, GA 30322 USA
[9]
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
[J].
Chang, Yanqi
;
Zhang, Xing
;
Horton, John R.
;
Upadhyay, Anup K.
;
Spannhoff, Astrid
;
Liu, Jin
;
Snyder, James P.
;
Bedford, Mark T.
;
Cheng, Xiaodong
.
NATURE STRUCTURAL & MOLECULAR BIOLOGY,
2009, 16 (03)
:312-317

Chang, Yanqi
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Zhang, Xing
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Horton, John R.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Upadhyay, Anup K.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Spannhoff, Astrid
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Dallas, Dept Carcinogenesis, MD Anderson Canc Ctr, Smithville, TX 78957 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Liu, Jin
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Chem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Snyder, James P.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Chem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Bedford, Mark T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Dallas, Dept Carcinogenesis, MD Anderson Canc Ctr, Smithville, TX 78957 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

Cheng, Xiaodong
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA
[10]
H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM
[J].
Chen, Min-Wei
;
Hua, Kuo-Tai
;
Kao, Hsin-Jung
;
Chi, Chia-Chun
;
Wei, Lin-Hung
;
Johansson, Gunnar
;
Shiah, Shine-Gwo
;
Chen, Pai-Sheng
;
Jeng, Yung-Ming
;
Cheng, Tsu-Yao
;
Lai, Tsung-Ching
;
Chang, Jeng-Shou
;
Jan, Yi-Hua
;
Chien, Ming-Hsien
;
Yang, Chih-Jen
;
Huang, Ming-Shyan
;
Hsiao, Michael
;
Kuo, Min-Liang
.
CANCER RESEARCH,
2010, 70 (20)
:7830-7840

Chen, Min-Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Hua, Kuo-Tai
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Kao, Hsin-Jung
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Chi, Chia-Chun
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Wei, Lin-Hung
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Johansson, Gunnar
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Shiah, Shine-Gwo
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Natl Inst Canc Res, Miaoli, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Chen, Pai-Sheng
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Jeng, Yung-Ming
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Dept Pathol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Cheng, Tsu-Yao
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Lai, Tsung-Ching
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Chang, Jeng-Shou
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Jan, Yi-Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Chien, Ming-Hsien
论文数: 0 引用数: 0
h-index: 0
机构:
Taipei Med Univ, Wang Fang Hosp, Taipei, Taiwan
Taipei Med Univ, Grad Inst Clin Med, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Yang, Chih-Jen
论文数: 0 引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Huang, Ming-Shyan
论文数: 0 引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Hsiao, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

Kuo, Min-Liang
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan