共 101 条
Targeting protein lysine methylation and demethylation in cancers
被引:52
作者:

He, Yunlong
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA

Korboukh, Ilia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA

Jin, Jian
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h-index: 0
机构:
Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA

Huang, Jing
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA
机构:
[1] Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA
[2] NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA
基金:
美国国家卫生研究院;
关键词:
methylation;
demethylation;
methyltransferase;
demethylase;
cancer;
epigenetics;
NF-KAPPA-B;
G9A HISTONE METHYLTRANSFERASE;
DOMAIN-CONTAINING PROTEINS;
BREAST-CANCER;
TRANSCRIPTIONAL REPRESSION;
SELECTIVE INHIBITORS;
CELL-PROLIFERATION;
STRUCTURAL BASIS;
PROSTATE-CANCER;
SILENCED GENES;
D O I:
10.1093/abbs/gmr109
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
During the last decade, we saw an explosion of studies investigating the role of lysine methylation/demethylation of histones and non-histone proteins, such as p53, NF-kappaB, and E2F1. These 'Ying-Yang' post-translational modifications are important to fine-tuning the activity of these proteins. Lysine methylation and demethylation are catalyzed by protein lysine methyl-transferases (PKMTs) and protein lysine demethylases (PKDMs). PKMTs, PKDMs, and their substrates have been shown to play important roles in cancers. Although the underlying mechanisms of tumorigenesis are still largely unknown, growing evidence is starting to link aberrant regulation of methylation to tumorigenesis. This review focuses on summarizing the recent progress in understanding of the function of protein lysine methylation, and in the discovery of small molecule inhibitors for PKMTs and PKDMs. We also discuss the potential and the caveats of targeting protein lysine methylation for the treatment of cancer.
引用
收藏
页码:70 / 79
页数:10
相关论文
共 101 条
[71]
Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
[J].
Schulte, Johannes H.
;
Lim, Soyoung
;
Schramm, Alexander
;
Friedrichs, Nicolaus
;
Koster, Jan
;
Versteeg, Rogier
;
Ora, Ingrid
;
Pajtler, Kristian
;
Klein-Hitpass, Ludger
;
Kuhfittig-Kulle, Steffi
;
Metzger, Eric
;
Schuele, Roland
;
Eggert, Angelika
;
Buettner, Reinhard
;
Kirfel, Jutta
.
CANCER RESEARCH,
2009, 69 (05)
:2065-2071

Schulte, Johannes H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Childrens Hosp Essen, Dept Paediat Oncol & Hematol, Essen, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Lim, Soyoung
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Pathol, D-53127 Bonn, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Schramm, Alexander
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Childrens Hosp Essen, Dept Paediat Oncol & Hematol, Essen, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Friedrichs, Nicolaus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Pathol, D-53127 Bonn, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Koster, Jan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Human Genet, NL-1105 AZ Amsterdam, Netherlands Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Versteeg, Rogier
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Human Genet, NL-1105 AZ Amsterdam, Netherlands Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Ora, Ingrid
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Human Genet, NL-1105 AZ Amsterdam, Netherlands
Univ Lund Hosp, Dept Pediat Oncol & Hematol, S-22185 Lund, Sweden Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Pajtler, Kristian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Childrens Hosp Essen, Dept Paediat Oncol & Hematol, Essen, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Klein-Hitpass, Ludger
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Essen, Inst Cell Biol, Essen, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Kuhfittig-Kulle, Steffi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Childrens Hosp Essen, Dept Paediat Oncol & Hematol, Essen, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Metzger, Eric
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Med Ctr, Clin Res Ctr, D-7800 Freiburg, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Schuele, Roland
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Med Ctr, Clin Res Ctr, D-7800 Freiburg, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Eggert, Angelika
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Childrens Hosp Essen, Dept Paediat Oncol & Hematol, Essen, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Buettner, Reinhard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Pathol, D-53127 Bonn, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

Kirfel, Jutta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Pathol, D-53127 Bonn, Germany Univ Bonn, Inst Pathol, D-53127 Bonn, Germany
[72]
(Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators
[J].
Sharma, Shiv K.
;
Wu, Yu
;
Steinbergs, Nora
;
Crowley, Michael L.
;
Hanson, Allison S.
;
Casero, Robert A., Jr.
;
Woster, Patrick M.
.
JOURNAL OF MEDICINAL CHEMISTRY,
2010, 53 (14)
:5197-5212

Sharma, Shiv K.
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA

Wu, Yu
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA

Steinbergs, Nora
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA

Crowley, Michael L.
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA

Hanson, Allison S.
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA

Casero, Robert A., Jr.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA

Woster, Patrick M.
论文数: 0 引用数: 0
h-index: 0
机构:
Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA Wayne State Univ, Dept Pharmaceut Sci, Detroit, MI 48202 USA
[73]
Modulation of p53 function by SET8-mediated methylation at lysine 382
[J].
Shi, Xiaobing
;
Kachirskaia, Loulia
;
Yamaguchi, Hiroshi
;
West, Lisandra E.
;
Wen, Hong
;
Wang, Evelyn W.
;
Dutta, Sucharita
;
Appella, Ettore
;
Gozani, Or
.
MOLECULAR CELL,
2007, 27 (04)
:636-646

Shi, Xiaobing
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

Kachirskaia, Loulia
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

Yamaguchi, Hiroshi
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

West, Lisandra E.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

Wen, Hong
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

Wang, Evelyn W.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

Dutta, Sucharita
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

Appella, Ettore
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

Gozani, Or
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA
[74]
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
[J].
Shi, YJ
;
Lan, F
;
Matson, C
;
Mulligan, P
;
Whetstine, JR
;
Cole, PA
;
Casero, RA
;
Shi, Y
.
CELL,
2004, 119 (07)
:941-953

Shi, YJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Lan, F
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Matson, C
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

论文数: 引用数:
h-index:
机构:

Whetstine, JR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Cole, PA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Casero, RA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Shi, Y
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[75]
Coordinated histone modifications mediated by a CtBP co-repressor complex
[J].
Shi, YJ
;
Sawada, J
;
Sui, GC
;
Affar, EB
;
Whetstine, JR
;
Lan, F
;
Ogawa, H
;
Luke, MPS
;
Nakatani, Y
;
Shi, Y
.
NATURE,
2003, 422 (6933)
:735-738

Shi, YJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Sawada, J
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Sui, GC
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Affar, EB
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Whetstine, JR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Lan, F
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Ogawa, H
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Luke, MPS
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Nakatani, Y
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Shi, Y
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[76]
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression
[J].
Strahl, BD
;
Grant, PA
;
Briggs, SD
;
Sun, ZW
;
Bone, JR
;
Caldwell, JA
;
Mollah, S
;
Cook, RG
;
Shabanowitz, J
;
Hunt, DF
;
Allis, CD
.
MOLECULAR AND CELLULAR BIOLOGY,
2002, 22 (05)
:1298-1306

Strahl, BD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Grant, PA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Briggs, SD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Sun, ZW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Bone, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Caldwell, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Mollah, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Cook, RG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Shabanowitz, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Hunt, DF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Allis, CD
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA Univ Virginia, Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA
[77]
Polycomb group protein Ezh2 controls actin polymerization and cell signaling
[J].
Su, I
;
Dobenecker, MW
;
Dickinson, E
;
Oser, M
;
Basavaraj, A
;
Marqueron, R
;
Viale, A
;
Reinberg, D
;
Wülfing, C
;
Tarakhovsky, A
.
CELL,
2005, 121 (03)
:425-436

Su, I
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

Dobenecker, MW
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

Dickinson, E
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

Oser, M
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

Basavaraj, A
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

Marqueron, R
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

Viale, A
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

论文数: 引用数:
h-index:
机构:

Wülfing, C
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

Tarakhovsky, A
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA
[78]
Regulation of estrogen receptor α by the SET7 lysine methyltransferase
[J].
Subramanian, Krithika
;
Da Jia
;
Kapoor-Vazirani, Priya
;
Powell, Doris R.
;
Collins, Robert E.
;
Sharma, Dipali
;
Peng, Junmin
;
Cheng, Xiaodong
;
Vertino, Paula M.
.
MOLECULAR CELL,
2008, 30 (03)
:336-347

Subramanian, Krithika
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Da Jia
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Kapoor-Vazirani, Priya
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Powell, Doris R.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Collins, Robert E.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Sharma, Dipali
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Hematol & Oncol, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Peng, Junmin
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Cheng, Xiaodong
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA

Vertino, Paula M.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA 30322 USA Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA
[79]
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
[J].
Tachibana, M
;
Ueda, J
;
Fukuda, M
;
Takeda, N
;
Ohta, T
;
Iwanari, H
;
Sakihama, T
;
Kodama, T
;
Hamakubo, T
;
Shinkai, Y
.
GENES & DEVELOPMENT,
2005, 19 (07)
:815-826

论文数: 引用数:
h-index:
机构:

Ueda, J
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Fukuda, M
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Takeda, N
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Ohta, T
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Iwanari, H
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Sakihama, T
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Kodama, T
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Hamakubo, T
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan

Shinkai, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Sakyo Ku, Kyoto 6068507, Japan
[80]
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
[J].
Tachibana, M
;
Sugimoto, K
;
Nozaki, M
;
Ueda, J
;
Ohta, T
;
Ohki, M
;
Fukuda, M
;
Takeda, N
;
Niida, H
;
Kato, H
;
Shinkai, Y
.
GENES & DEVELOPMENT,
2002, 16 (14)
:1779-1791

Tachibana, M
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Sugimoto, K
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Nozaki, M
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Ueda, J
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机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Ohta, T
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机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Ohki, M
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机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Fukuda, M
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机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

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Niida, H
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机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Kato, H
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机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan

Shinkai, Y
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机构: Kyoto Univ, Inst Virus Res, Dept Cell Biol, Kyoto 6068507, Japan