Facile synthesis of 2-nitroalkanols by tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones

被引:71
作者
Simoni, D
Invidiata, FP
Manfredini, S
Ferroni, R
Lampronti, I
Roberti, M
Pollini, GP
机构
[1] UNIV FERRARA,DIPARTIMENTO SCI FARMACEUT,I-44100 FERRARA,ITALY
[2] UNIV BOLOGNA,DIPARTIMENTO SCI FARMACEUT,I-40126 BOLOGNA,ITALY
关键词
D O I
10.1016/S0040-4039(97)00461-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Tetramethylguanidine-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones constitutes a practical means to perform the nitro-aldol reaction (Henry reaction). The very mild conditions employed, together with the short reaction times, make the procedure tolerant of a range of functionalities and highly versatile for the synthesis of a variety of 2-nitroalkanols. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:2749 / 2752
页数:4
相关论文
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