SREBPs: physiology and pathophysiology of the SREBP family

被引：163

作者：

Shimano, Hitoshi ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Internal Med Endocrinogl & Metab, Tsukuba, Ibaraki 3058575, Japan

来源：

FEBS JOURNAL | 2009年 / 276卷 / 03期

关键词：

cholesterol; diabetes; dyslipidemia; fatty acids; fatty liver; insulin resistance; lipotoxicity; metabolic syndrome; SREBP; trigylcerides; ELEMENT-BINDING PROTEIN-1; POLYUNSATURATED FATTY-ACIDS; RENAL LIPID-METABOLISM; DEPENDENT KINASE INHIBITOR; LIPOGENIC GENE-EXPRESSION; BETA-CELL DYSFUNCTION; TRANSCRIPTION FACTOR; INSULIN-SECRETION; SYNTHASE EXPRESSION; ADIPOCYTE DIFFERENTIATION;

D O I：

10.1111/j.1742-4658.2008.06806.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sterol regulatory element-binding proteins (SREBPs) have been established as physiological regulators of lipid synthesis. The molecular mechanisms by which cellular sterol balance and nutritional states regulate SREBP activities are the current research focus of this field. Meanwhile, it has been shown that overnutrition or disturbed energy balance causes accumulation of tissue lipids, leading to metabolic disorders, often referred to as 'lipotoxicity'. In this overview, I discuss the pathological aspects of SREBPs, which contribute to lipotoxicity in a wide variety of organs, including hepatic insulin resistance in hepatosteatosis, impaired insulin secretion in pancreatic beta-cells, diabetic nephropathy, cardiac arrythmiasis, and obesity.

引用

页码：616 / 621

页数：6

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