Exceptionally high Felkin-Anh control for the addition of nucleophiles to a beta-aminocyclopropylcarbaldehyde

被引:14
作者
Bubert, C
Reiser, O
机构
[1] UNIV STUTTGART,INST ORGAN CHEM,D-70569 STUTTGART,GERMANY
[2] UNIV GOTTINGEN,INST ORGAN CHEM,D-37077 GOTTINGEN,GERMANY
关键词
D O I
10.1016/S0040-4039(97)01065-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Exceptionally high diastereocontrol in agreement with the Felkin-Anh model was observed for the addition of nucleophiles to the beta-aminocyclopropylcarbaldehyde 5 in nitroaldol, cyanohydrin, Mukaiyama aldol, and Sakurai reactions, contrasting the low diastereoselectivities generally observed in additions to cyclopropylcarbaldehydes. (C) 1997 Elsevier Science Ltd.
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页码:4985 / 4988
页数:4
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