Relationship between salt-bridge identity and 14-helix stability of β3-peptides in aqueous buffer

被引：21

作者：

Guarracino, DA ^{[1
]}

Chiang, HJR

Banks, TN

Lear, JD

Hodsdon, ME

Schepartz, A

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys, New Haven, CT 06520 USA

[3] Yale Univ, Dept Biochem, New Haven, CT 06520 USA

[4] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[5] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[6] Yale Sch Med, Dept Lab Med, New Haven, CT 06510 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 05期

关键词：

D O I：

10.1021/ol0527532

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a systematic analysis of the relationship between salt bridge composition and 14-helix structure within a family of model beta-peptides in aqueous buffer. We find an inverse relationship between side-chain length and the extent of 14-helix structure as judged by CID. Introduction of a stabilizing salt bridge pair within a previously reported beta-peptide ligand for hDM2 led to changes in structure that were detectable by NMR.

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页码：807 / 810

页数：4

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