Recent advances in array comparative genomic hybridization technologies and their applications in human genetics

被引：63

作者：

Lockwood, WW ^{[1
]}

Chari, R ^{[1
]}

Chi, B ^{[1
]}

Lam, WL ^{[1
]}

机构：

[1] British Columbia Canc Res Ctr, Vancouver, BC V5Z 1L3, Canada

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2006年 / 14卷 / 02期

关键词：

array CGH; matrix CGH; cancer genome; cancer genetics; genetic disease; copy number alteration; array CGH software;

D O I：

10.1038/sj.ejhg.5201531

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Array comparative genomic hybridization (arrayCGH) is a method used to detect segmental DNA copy number alterations. Recently, advances in this technology have enabled high-resolution examination for identifying genetic alterations and copy number variations on a genome-wide scale. This review describes the current genomic array platforms and CGH methodologies, highlights their applications for studying cancer genetics, constitutional disease and human variation, and discusses visualization and analytical software programs for computational interpretation of array CGH

引用

页码：139 / 148

页数：10

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