Crystallisation of α-lactose monohydrate from dimethyl sulfoxide (DMSO) solutions:: influence of β-lactose

被引：53

作者：

Dincer, TD ^{[1
]}

Parkinson, GM ^{[1
]}

Rohl, AL ^{[1
]}

Ogden, MI ^{[1
]}

机构：

[1] Curtin Univ Technol, Sch Appl Chem, Perth, WA 6845, Australia

来源：

JOURNAL OF CRYSTAL GROWTH | 1999年 / 205卷 / 03期

关键词：

lactose; morphology; atomic force microscopy; molecular modelling;

D O I：

10.1016/S0022-0248(99)00238-9

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In this study, the dimethyl sulfoxide (DMSO)-lactose system has been used to study the effect of beta-lactose on the morphology of alpha-lactose monohydrate crystals. DMSO was used as the solvent as it greatly reduces the rate of mutarotation of alpha-lactose to beta-lactose. It is shown that as the beta-content of the solution increases, the crystal shape starts increasing in the a and b directions, whereas the major growth occurs in the c direction at low levels of beta-lactose. The morphology of the alpha-lactose monohydrate crystal calculated by molecular modelling is in good agreement with that of the crystals grown in the presence of low beta-lactose concentrations. Atomic force microscopy has revealed growth spirals and unit cell high steps on the (0 2 0) face of crystals grown in the presence of low beta-anomer concentration. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：368 / 374

页数：7

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